IgA-producing lymphoplasmacytic lymphoma carrying the chromosomal abnormality t(8;14)

IgA producing primary intracerebral lymphoma.

The first case of a primary and solitary IgA (lambda) producing tumour (possibly a non-Hodgkin's lymphoma) in the CNS is reported. Clinical and neuroimaging findings are described. Early diagnosis without brain biopsy and successful therapy were possible by CSF and serum immunoglobulin analysis which proved local paraprotein production restricted to the CNS.

Waldenstrom's macrogloblinemia/ lymphoplasmacytic lymphoma.

Waldenström’s macroglobulinemia (WM) is a distinct clinicopathological entity resulting from the accumulation, predominantly in the bone marrow, of clonally related lymphocytes, lymphoplasmacytic cells and plasma cells which secrete a monoclonal IgM protein (Figure 1). This condition is considered to correspond to the lymphoplasmacytic lymphoma (LPL) as defined by the Revised European American ...

Response to ibrutinib in a patient with IgG lymphoplasmacytic lymphoma carrying the MYD88 L265P gene mutation.

Response to ibrutinib in a patient with IgG lymphoplasmacytic lymphoma carrying the MYD88 L265P gene mutation Jorge J. Castillo, Irene M. Ghobrial & Steven P. Treon To cite this article: Jorge J. Castillo, Irene M. Ghobrial & Steven P. Treon (2016) Response to ibrutinib in a patient with IgG lymphoplasmacytic lymphoma carrying the MYD88 L265P gene mutation, Leukemia & Lymphoma, 57:11, 2699-2701...

Chromosomal Abnormality in Men with Impaired Spermatogenesis

Consanguinity and chromosomal abnormality

BACKGROUND: Consanguinity is defined as the marriage between close relatives. The deleterious effects associated with consanguinity may be caused by the expression of rare recessive genes inherited from common ancestors. AIMS AND OBJECTIVES: The present study was undertaken to analyze the effect of consanguinity on chromosomal abnormality (CA). METHODS AND MATERIALS: During last 6 years period,...